Patterns of Nucleotide Substitution in Angiosperm cpDNA trnL (UAA)–trnF (GAA) Regions

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Patterns of nucleotide and amino acid substitution

So I’ve just suggested that the neutral theory of molecular evolution explains quite a bit, but it also ignores quite a bit. The derivations we did assumed that all substitutions are equally likely to occur, because they are selectively neutral. That isn’t plausible. We need look no further than sickle cell anemia to see an example of a protein polymorphism in which a single amino acid differen...

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Patterns of nucleotide and amino acid substitution

So I’ve just suggested that the neutral theory of molecular evolution explains quite a bit, but it also ignores quite a bit. The derivations we did assumed that all substitutions are equally likely to occur, because they are selectively neutral. That isn’t plausible. We need look no further than sickle cell anemia to see an example of a protein polymorphism in which a single amino acid differen...

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ژورنال

عنوان ژورنال: Molecular Biology and Evolution

سال: 2000

ISSN: 1537-1719,0737-4038

DOI: 10.1093/oxfordjournals.molbev.a026397